Search results for "3D coculture"

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3d collagen hydrogel promotes in vitro langerhans islets vascularization through ad-mvfs angiogenic activity

2021

Adipose derived microvascular fragments (ad-MVFs) consist of effective vascularization units able to reassemble into efficient microvascular networks. Because of their content in stem cells and related angiogenic activity, ad-MVFs represent an interesting tool for applications in regenerative medicine. Here we show that gentle dissociation of rat adipose tissue provides a mixture of ad-MVFs with a length distribution ranging from 33–955 μm that are able to maintain their original morphology. The isolated units of ad-MVFs that resulted were able to activate transcriptional switching toward angiogenesis, forming tubes, branches, and entire capillary networks when cultured in 3D collagen type-…

0301 basic medicineMMP2QH301-705.5Angiogenesis0206 medical engineeringMedicine (miscellaneous)Adipose tissue3D coculture02 engineering and technologyRegenerative medicineGeneral Biochemistry Genetics and Molecular BiologyArticleExtracellular matrix03 medical and health sciencesmedicineBiology (General)Islet of LangerhansTransplantationChemistry020601 biomedical engineeringCell biologyTransplantationMicrovascular fragments030104 developmental biologymedicine.anatomical_structureBasal laminaAngiogenesisStem cell3D coculture; Angiogenesis; Islet of Langerhans; Microvascular fragments; Transplantation

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PEPhysical Sciences and Engineering
- PE2Fundamental Constituents of Matter
  - PE2_1Theory of fundamental interactions
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LSLife Sciences
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- LS2Integrative Biology: from Genes and Genomes to Systems
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  - LS2_16Innovative methods and modelling in integrative biology
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  - LS4_1Organ and tissue physiology and pathophysiology
  - LS4_4Endocrinology
  - LS4_3Physiology of ageing
  - LS4_2Comparative physiology
  - LS4_5Non-hormonal mechanisms of inter-organ and tissue communication
  - LS4_6Microbiome and host physiology
  - LS4_7Nutrition and exercise physiology
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  - LS3_8Embryogenesis, pattern formation, morphogenesis
  - LS3_9Cell differentiation, formation of tissues and organs
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  - LS3_11Evolution of developmental strategies
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  - LS3_13Stem cells
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  - LS3_15Development of cell-based therapeutic approaches for tissue regeneration
  - LS3_17Theoretical modelling in cellular, developmental and regenerative biology
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  - LS3_1Cell cycle, cell division and growth
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  - LS5_1Neuronal cells
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SHSocial Sciences and Humanities
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